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The additional adipose tissue in heavier individuals creates a larger target for the peptide but also means more tissue requires the signal to release stored lipids

Intravenous edaravone treatment in ALS and survival: an exploratory, retrospective, administrative claims analysis

by reducing aberrant Ca 2+ influx, it can prevent calcium-mediated excitotoxicity and mitochondrial dysfunction in neurons (40)

For patient accrual, treatment and adverse events, clinical outcomes, and major PK parameters, refer to ref